Brucellosis and its treatment with Doxycycline

Brucellosis, which is also called Crimean fever or Bang’s disease, is a zoonosis caused by consumption of unsterilized milk, infected meat or contact with animal’s secretions. Where can i buy doxycycline.

Brucellosis may develop in cattle, dogs, and other animals. It may be transmitted through breeding or contact with aborted fetuses. The disease can occur in humans who come in contact with aborted tissue or semen. Transmission in humans, from mother to child or through sexual contact, is rare but possible. The bacterium which causes Brucellosis is intracellular parasites leading to chronic disease, which may persist for life. Symptoms include joint and muscle pain and profuse sweating. The disease has been recognized both in animals and humans since the twentieth century.

Brucellosis in humans is associated with the ingestion of unsterilized milk or soft cheese made from milk of the cattle infected with Brucella melitensis or with exposure of laboratory workers or veterinarians. Some accidentally injected vaccines may also cause this condition in humans. Brucellosis causes sweating, inconstant fevers, weakness, headache, anemia, depression, and muscle pain. The symptoms are similar to those associated with other febrile diseases with more emphasis on muscle pain and sweating.

The disease can last from several weeks to months or even years. The first stage of the Brucellosis is characterized by undulant fevers, sweating, and change of smell. On this stage the blood tests usually reveal anemia and leucopenia, increase of AST and ALT, and positive Huddleston and Bengal Rose reactions. If the condition remains untreated, it can give ground to focalizations or, what is even worse, become chronic. The brucellosis focalizations may occur in bones and joints accompanied by sacroiliitis.

Diagnosis of brucellosis is based on demonstration of the agent, demonstration of antibodies against the agent, histological evidence of hepatitis, and radiologic alterations in vertebrae.

Antibiotics from tetracyclines family, streptomycin, and gentomicyn have shown to be effective against B. bacteria. However, the doctors recommend using more than one antibiotic during treatment, because the bacteria incubate in cells.

The standard treatment for adults includes intramuscular daily injections of streptomycin for 14 days and oral doxycycline 100 mg twice a day for 45 days. Streptomycin may be substituted with Gentamicin, but doxycycline should be taken as prescribed. Another way to treat the disease is a combination of doxycycline with rifampin twice a day for about 6 weeks or more. A triple therapy of doxycycline, combined with cotrimoxazole and rifampin, has been used effectively to treat neurobrucellosis. Doxycycline can help cross the blood–brain barrier, but should be taken together with two other drugs to avoid relapse.

To prevent brucellosis it is recommended to pasteurize the milk which is to be ingested by humans, either in its original form or a derivate, such as cheese.